PEDIATRICS Vol. 74 No. 3 September 1984, pp. 443
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Fungal Infections in Premature Infants

JILL E. BALEY MD1, ROBERT M. KLIEGMAN MD1, and AVROY A. FANAROFF MD1

1 Department of Pediatrics, Case Western Reserve University, Rainbow Babies and Childrens Hospital, 2101 Adelbert Rd, Cleveland, OH 44106

In Reply.—

Seventy percent of the low-birth-weight (LBW) infants whose condition was clinically diagnosed as systemic fungal infections demonstrated glucose intolerance. Langdon is correct that hyperglycemia, which may be found in young diabetic women, may encourage nonsystemic or local candidiasis. He is also correct that multiple factors may affect glucose tolerance in the sick low-birth-weight infant. Whereas it is possible that alterations in care or glucose intake might result in hyperglycemia, it is unusual for a low-birth-weight infant who has previously demonstrated stable glucose control to suddenly develop hyperglycemia and/or glycosuria at 5 weeks of age.