PEDIATRICS Vol. 74 No. 1 July 1984, pp. 86-89
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Antibody Production Following Immunization with Diphtheria and Tetanus Toxoids in Children Receiving Chemotherapy During Remission of Malignant Disease

F. H. Kung MD1, H. A. Orgel MD1, W. W. Wallace MD1, and R. N. Hamburger MD1

1 From the Department of Pediatrics, University of California, San Diego, School of Medicine, La Jolla

Twenty-seven children with various childhood malignancies who were in clinical remission and receiving maintenance chemotherapy were given diphtheria-pertussis-tetanus (DPT) immunizations. Antidiphtheria and antitetanus titers were drawn before and 1 month after immunization. Only one child had no antibody response to either antigen. Two other children failed to develop any detectable antitetanus antibody titer but did mount a normal antibody response to inactivated diphtheria antigen. In fact, most children made good antibody responses to both immunizing antigens, irrespective pective of the nature of their disease or of the treatment given. These results show that children receiving longterm chemotherapy should not be denied the protection afforded by immunization with nonliving vaccines.

Key Words: diphtheria • tetanus toxoids • immunization • chemotherapy • antibody response

Submitted on February 14, 1983
Accepted on October 5, 1983




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