PEDIATRICS Vol. 74 No. 1 July 1984, pp. 32-36
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Timing and Antecedents of Intracranial Hemorrhage in the Newborn

Marilyn M. McDonald MD1, Beverly L. Koops MD1, Michael L. Johnson MD1, Mary Anne Guggenheim MD1, Carol M. Rumack MD1, Sharon A. Mitchell RN1, and William E. Hathaway MD1

1 From the Departments of Pediatrics and Radiology, University of Colorado School of Medicine, Denver

Fifty newborn infants of less than 33 weeks' gestation were followed prospectively from birth to evaluate the temporal relationships of various clinical factors to the onset and progression of intracranial hemorrhage (ICH) in an inborn population given maximal support. ICH was diagnosed and followed with bedside ultrasound every eight hours. The incidence of intraventricular hemorrhage was 30% and of any ICH was 40% with onset from less than 2 hours to 8 days of age. Grades 2, 3, and 4 ICH correlated with Apgar scores of less than 5 at five minutes, vaginal delivery, longer labors, and intrapartum hemorrhage. There was a significant correlation between ICH and both blood pressure fluctuations of greater than 100% and rapid colloid infusions. Slow transfusions of packed red cells did not appear to precipitate episodes of ICH. In a setting of optimal care, ICH appears to be more related to prenatal stresses than to specific postnatal complications.

Key Words: newborn • intracranial hemorrhage

Submitted on December 28, 1982




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