PEDIATRICS Vol. 74 No. 1 July 1984, pp. 26-31
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McDonald, M. M.
Right arrow Articles by Hathaway, W. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McDonald, M. M.
Right arrow Articles by Hathaway, W. E.

Role of Coagulopathy in Newborn Intracranial Hemorrhage

Marilyn M. McDonald MD.1, Michael L. Johnson MD1, Carol M. Rumack MD1, Beverly L. Koops MD1, Mary Anne Guggenheim MD1, Cynthia Babb RN1, and William E. Hathaway MD1

1 From the Departments of Pediatrics and Radiology, University of Colorado School of Medicine, Denver

Fifty newborn infants of less than 33 weeks' gestation were followed prospectively from birth with serial coagulation and real-time ultrasound studies. A significant association of hypocoagulability in the first four hours of life with subsequent onset or progression of intraventricular or other clinical hemorrhages was documented. Abnormalities included lower values for fibrinogen, platelet count, antithrombin III, and factor VIII with higher values for fibrin monomer and longer Laidlaw whole blood clotting times. These abnormalities tended to correct spontaneously in surviving infants. An association between gestational complications and incidence of hypocoagulability and intracranial hemorrhage (ICH) was noted. Babies of preeclamptic mothers had fewer abnormalities and babies born to mothers with premature rupture of membranes and suspected amnionitis manifested more hypocoagulability and more severe intracranial hemorrhages.

Key Words: coagulopathy • newborn • intracranial hemorrhage

Submitted on December 28, 1982




This article has been cited by other articles:


Home page
 J. Thorac. Cardiovasc. Surg.Home page
J. Petaja, K. Peltola, H. Sairanen, M. Leijala, R. Kekomaki, E. Vahtera, and M. A. Siimes
FIBRINOLYSIS, ANTITHROMBIN III, AND PROTEIN C IN NEONATES DURING CARDIAC OPERATIONS
J. Thorac. Cardiovasc. Surg., September 1, 1996; 112(3): 665 - 671.
[Abstract] [Full Text]

Home page
 NEJMHome page
M. E. Norton, J. Merrill, B. Cooper, J. A. Kuller, and R. I. Clyman
Neonatal Complications after the Administration of Indomethacin for Preterm Labor
N. Engl. J. Med., November 25, 1993; 329(22): 1602 - 1607.
[Abstract] [Full Text]