PEDIATRICS Vol. 73 No. 6 June 1984, pp. 880-881
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Percutaneous Absorption of Iodochlorhydroxyquin in Humans and Dogs

S. J. STOHS PHD1 and F. W. EZZEDEEN PHD1

1 Department of Biomedicinal Chemistry, University of Nebraska Medical Center, Omah, NE 68105

To the Editor.—

Iodochlorhydroxyquin (Clioquinol, Vioform) has been widely used for the prophylaxis of traveler's diarrhea, treatment of amoebic dysentery, and the management of fungal infections, although its medical value has been questioned.1 However, its oral use has been severely restricted in recent years due to its potential for neurotoxicity,2,3 hepatoxicity and nephrotoxicity.3,4 Iodochlorhydroxyquin, is still used widely in the treatment of diaper rash and other skin disorders, and it is presumed to undergo little percutaneous absorption.