PEDIATRICS Vol. 73 No. 6 June 1984, pp. 878
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Theophylline Poisoning

MILES WEINBERGER MD1

1 Pediatric Allergy and Pulmonary Division, The University of Iowa, Iowa City, IA 52242

To the Editor.—

The conclusions in the recent letter by Kossoy et al1 and the reply by Sahney2 regarding the original report3 suggesting conservative treatment of high theophylline levels until neurologic signs are present do not adequately consider the high frequency of mortality and serious neurologic sequelae once theophylline-induced seizures occur.4,5 Unfortunately, the chemical success of charcoal hemoperfusion after the onset of seizures has not been matched by the desired clinical results.6 Although the risks of vigorous intervention in a patient not yet having serious symptoms must be considered, the small number of cases reported without serious consequences should not provide great reassurance given the potentially serious outcome, ie, death or brain damage, that commonly follows onset of the seizures even in the presence of subsequent dialysis and otherwise optimal intensive care.




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H. C. Mofenson, T. R. Caraccio, J. Greensher, R. D'Agostino, and A. Rossi
Gastrointestinal Dialysis with Activated Charcoal and Cathartic in the Treatment of Adolescent Intoxications
Clinical Pediatrics, December 1, 1985; 24(12): 678 - 684.
[Abstract] [PDF]