PEDIATRICS Vol. 73 No. 4 April 1984, pp. 459-466
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chesney, R. W.
Right arrow Articles by Mazess, R. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chesney, R. W.
Right arrow Articles by Mazess, R. B.

Persistence of Diminished Bone Mineral Content Following Renal Transplantation in Childhood

Russell W. Chesney MD1, Philip G. Rose BS1, and Richard B. Mazess PhD1

1 From the Pediatric Renal Disease Laboratory, Departments of Pediatrics, Radiology, and Medical Physics, University of Wisconsin Center for Health Sciences, Madison

Bone mineral content (BMC) was measured in the nondominant arm of 18 children (aged 37/12 to 17frac12 years) for a total 783 months after renal transplantation. Using photon absorptiometry, 89 measurements were made; 17 of the 18 patients had a functioning graft and one patient died. Significant demineralization, a BMC greater than -2 SD below appropriate control volumes, was found in 11 of 18 patients (62%) and 55 of 89 measurements (61%). Bone loss was progressive; among the 16 patients followed for more than 6 months, ten showed a decline of more than 0.5 SD in BMC, five had no change, and only one showed improvement. No relationship was found between BMC and the use of furosemide, type of transplant (15 living, seven cadaver), prior renal disease (six with glomerulonephritis, 11 tubulointerstitial), need for a second graft (five patients), chronic anticonvulsant therapy, or serum calcium and phosphate values. BMC was slightly correlated (P < .05) with alkaline phosphatase values. BMC was more strongly correlated with serum creatinine (y = -0.48x + 1.25, r = -.042, P < .001) and prednisone dose (mg/kg/d) (y = -0.65x + 0.481, r = -.543, P < .001) in an inverse relationship. Patients whose serum creatinine value was less than 1 mg/dL had a BMC of -0.71 ± 0.34 SD; those with serum creatinine value greater than 2 mg/dL had BMC of -3.32 ± 0.31 SD, different at P < .001. Patients receiving daily prednisone therapy had a significantly lower BMC than those receiving alternate-day therapy (-3.11 ± 1.23 SD v -1.72 ± 1.29 SD, P < .005).

Key Words: renal transplantation • glucocorticoids • bone demineralization • Photon absorptiometry

Submitted on April 15, 1983
Accepted on June 2, 1983




This article has been cited by other articles:


Home page
 Arch. Dis. Child.Home page
G. S Reusz, A. J Szabo, F. Peter, E. Kenesei, P. Sallay, K. Latta, A. Szabo, A. Szabo, and T. Tulassay
Bone metabolism and mineral density following renal transplantation
Arch. Dis. Child., August 1, 2000; 83(2): 146 - 151.
[Abstract] [Full Text] [PDF]