PEDIATRICS Vol. 73 No. 4 April 1984, pp. 435-439
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bedard, M. P.
Right arrow Articles by Poland, R. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bedard, M. P.
Right arrow Articles by Poland, R. L.

Effect of Prophylactic Phenobarbital on Intraventricular Hemorrhage in High-Risk Infants

Mary P. Bedard MD1, Seetha Shankaran MD1, Thomas L. Slovis MD1, Alfonso Pantoja MD1, Bimleshwar Dayal MD1, and Ronald L. Poland MD1

1 From the Departments of Pediatrics and Radiology, Children's Hospital of Michigan and Wayne State University, Detroit

Forty-two premature infants less than 24 hours of age, with normal admission echoencephalograms, were randomly assigned to control or phenobarbital treatment groups. Infants in the treated group received two loading doses of 10 mg/kg of phenobarbital 12 hours apart, followed by a maintenance dose of 2.5 mg/kg every 12 hours for 6 days. Serial echoencephalograms were obtained in both groups. The groups were comparable with regard to birth weight, gestational age, and potential risk factors for subependymal-intraventricular hemorrhage. Ten infants (48%) in each group developed hemorrhage. The hemorrhages in the phenobarbital-treated group were significantly less severe than those in the control group. The phenobarbital-treated infants who bled, however, were also significantly larger and more mature than control infants who bled. The results of this study indicate no effect of phenobarbital on the incidence of subependymal-intraventricular hemorrhage, but a possible beneficial effect on the severity of hemorrhage.

Key Words: phenobarbital prophylaxis • intraventricular hemorrhage

Submitted on May 31, 1983
Accepted on November 10, 1983




This article has been cited by other articles:


Home page
 J Child NeurolHome page
V. S. Miller
Topical Review Article: Pharmacologic Management of Neonatal Cerebral Ischemia and Hemorrhage: Old and New Directions
J Child Neurol, January 1, 1993; 8(1): 7 - 18.
[Abstract] [PDF]

Home page
 J Child NeurolHome page
J. Goddard-Finegold and E. M. Mizrahi
Review Article: Understanding and Preventing Perinatal, Intracerebral, Peri- and Intraventricular Hemorrhage
J Child Neurol, July 1, 1987; 2(3): 170 - 185.
[Abstract] [PDF]