PEDIATRICS Vol. 73 No. 3 March 1984, pp. 412
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Hemorrhagic Periventricular Leukomalacia and Spastic Diplegia

M. I. LEVENE MD1, J. S. WIGGLESWORTH MD, FRCPATH1, and V. DUBOWITZ MD, FRCP1

1 Department of Child Health, Leicesten University Medical School, Leicester, England

In Reply.—

We are in complete agreement with Kuban and Gilles on the continued importance of pathologic verification as the gold standard to which clinical diagnostic techniques are compared, and this remains the major basis of our own work, although such verification is inevitably limited by low mortality rates and problems in obtaining consent for autopsy. The points they make on the specificity of the areas of increased echodensity which we have equated with hemorrhagic periventricular leukomalacia (PVL) are important.