PEDIATRICS Vol. 73 No. 2 February 1984, pp. 218-224
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Intestinal Lesions Containing Coronavirus-like Particles in Neonatal Necrotizing Enterocolitis: An Ultrastructural Analysis

S. Rousset PhD1, O. Moscovici MD1, P. Lebon MD1, J. P. Barbet MD1, P. Helardot MD1, B. Macé MD1, F. Bargy MD1, Le Tan Vinh MD1, and C. Chany MD1

1 From the Institut National de la Santé et de la Recherche Médicale-Unité 43, Laboratoire d'Anatomie pathologique, and Département de Chirurgie, Hôpital Saint Vincent-de-Paul, Paris

Since the outbreaks of neonatal necrotizing enterocolitis occurring in maternity hospitals of Paris and suburbs in 1979-1980, it has been possible to examine by light and electron microscopy gut specimens from ten newborns with this illness. Coronavirus-like particles, enclosed in intracytoplasmic vesicles of damaged epithelial cells of the intestinal mucosa, were observed in the small intestine, appendix, and colon. The ultrastructural study, supported by bacteriologic findings, suggests the role of coronavirus-like particles in the appearance of the lesions. Secondary proliferation of mainly anaerobic bacteria, probably responsible for pneumatosis, may aggravate the disease.

Key Words: necrotizing • enterocolitis • newborns • coronavirus • ultrastructural study of lesions

Submitted on November 1, 1982
Accepted on April 26, 1983




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C. A. Hufnal-Miller, L. Blackmon, S. Baumgart, and G. R. Pereira
Enteral Theophylline and Necrotizing Enterocolitis in the Low-Birthweight Infant
Clinical Pediatrics, November 1, 1993; 32(11): 647 - 653.
[Abstract] [PDF]