PEDIATRICS Vol. 73 No. 1 January 1984, pp. 64-67
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mitsuoka, J. C.
Right arrow Articles by Fleck, R. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mitsuoka, J. C.
Right arrow Articles by Fleck, R. J.

A System for Individualized Dosing of Intravenous Aminophylline Using a Programmable Calculator

J. Chris Mitsuoka PharmD1 and Richard J. Fleck PharmD1

1 From the Department of Pharmacy, University of California Davis Medical Center, Sacramento, and Clinical Pharmacokinetics/Dynamics Section, Medical Division, Burroughs Wellcome Co, Research Triangle Park, North Carolina

A program that calculates a value of clearance for an individual patient prior to reaching steady state in the early stages of aminophylline therapy is presented. The program is written for the Texas Instruments TI-59 programmable calculator and may be used with or without the PC-100C printer. The program can provide clinically useful information concerning projected plasma concentrations prior to reaching steady state with an accurate history of the dose administration and serum concentration determination. If the patient has not received xanthene therapy prior to admission, only one serum sample is required. If there has been prior drug exposure, a second serum sample is required. An iterative technique, which would be impractical to use without calculator assistance, is employed to make these determinations.

Key Words: programmable calculator • clinical pharmacokinetics • theophylline • aminophylline • therapeutic drug monitoring

Submitted on March 14, 1983
Accepted on June 2, 1983