PEDIATRICS Vol. 73 No. 1 January 1984, pp. 52-55
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Esophageal Spasm Associated with Apnea and Bradycardia in an Infant

Julio Pérez Fontán MD1, Gregory P. Heldt MD1, Melvin B. Heyman MD1, Mark S. Marin BS1, and William H. Tooley MD1

1 From the Cardiovascular Research Institute and Department of Pediatrics, University of California in San Francisco, San Francisco

A newborn infant was found to have diffuse esophageal spasm in association with apnea and bradycardia. This association has not been physiologically documented before. The infant's condition improved after the administration of glycopyrrolate, an anticholinergic agent. It is speculated that the association of esophageal spasm and bradycardia may be mediated by the vagus.

Key Words: apnea • bradycardia • diffuse esophageal spasm • gastroesophageal reflux • sudden infant death syndrome

Submitted on January 21, 1983
Accepted on April 7, 1983