PEDIATRICS Vol. 72 No. 6 December 1983, pp. 818-822
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Pediatric Bone Marrow Transplantation: Current Progress and Future Prospects

PAUL M. SONDEL MD, PHD1, MICHAEL E. TRIGG MD1, RICHARD HONG MD1, JONATHAN L. FINLAY MB, CHB1, and MAREK J. BOZDECH MD1

1 Departments of Pediatrics, Human Oncology, Genetics, and Medicine University of Wisconsin, Madison

Allogeneic bone marrow transplantation (BMT) has been applied with increasing frequency and success to the treatment of children with severe immune deficiency disease,1,2 aplastic anemia,3,4 and the acute leukemias.5,8 Patients with these otherwise rapidly fatal diseases receive an intravenous infusion of marrow from a healthy donor. The healthy marrow either "replaces" the deficient marrow of children with immune deficiency or aplastic anemia, or "rescues" the marrow of children who have received ablative antileukemic therapy. The resultant engraftment makes the patient a chimera, with reconstitution of mature hematopoietic and immunologic cells of donor origin. When successful, this results in long-term survival with normal marrow function, no recurrence of the original disease, and a return to normal childhood activity and function with only a few irreversible but major side effects (such as infertility following total body irradiation).9