PEDIATRICS Vol. 72 No. 6 December 1983, pp. 813-816
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Amiodarone in Control of Sustained Tachyarrhythmias in Children with Wolff-Parkinson-White Syndrome

ELI SHAHAR MD1, ZOHAR BARZILAY MD1, MIRA FRAND MD2, and AMI FEIGL MD3

1 Pediatric Intensive Care Unit
2 Department of Pediatrics C, Chaim Sheba Medical Center, Tel-Hashomer
3 Pediatric Cardiologic Unit, Rehovot, Israel

The Wolff-Parkinson-White syndrome in children is often associated with rapid supraventricular tachyarrhythmias.1-4 Commonly, these arrhythmias are of brief duration and respond promptly to conventional medications. In some patients, however, cardiovascular compromise and even circulatory collapse may supervene due to a prolonged arrhythmia resistant to various pharmacologic agents. The wide spectrum of medications, such as digoxin, quinidine, propranolol, and verapamil, used in order to control and prevent these arrhythmias in children with Wolff-Parkinson-White syndrome indicates lack of optimal therapy.1-4 Surgical interruption of the accessory pathway has also been undertaken.5

Recent experience with amiodarone hydrochloride, a relatively new antiarrhythmic drug, has shown favorable effects in adult patients with Wolff-Parkinson-White syndrome and recurrent arrhythmias following failure of traditional medications.6-9