PEDIATRICS Vol. 72 No. 5 November 1983, pp. 613-618
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Ribavirin Aerosol Treatment of Bronchiolitis Associated with Respiratory Syncytial Virus Infection in Infants

Larry H. Taber MD1, Vernon Knight MD1, Brian E. Gilbert PhD1, Harvey W. McClung MD1, Samuel Z. Wilson BA1, H. James Norton MS1, Jeffrey M. Thurson MD1, Wayne H. Gordon MD1, Robert L. Atmar MD1, and W. Robin Schlaudt MD1

1 From the Department of Microbiology and Immunology and the Myers-Black Section of Infectious Disease, Department of Pediatrics, Baylor College of Medicine, Houston

In a double-blind study, bronchiolitis associated with respiratory syncytial virus infection in 12 randomly selected patients treated with ribavirin aerosol improved more rapidly than in 14 control patients given saline aerosol (P = .044, Wilcoxon rank sum test, two-tailed). An estimated 10 mg of ribavirin per kilogram of body weight was administered in daily 12-hour treatments over a five-day period. Respiratory syncytial virus disappeared from secretions at about the same rate in treated and control patients. There was no local or systemic intolerance, and there was no evidence of hematologic or other organ toxicity in the ribavirin-treated patients.

Key Words: bronchiolitis • ribavirin • respiratory syncytial virus

Submitted on October 27, 1982
Accepted on January 14, 1983




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