PEDIATRICS Vol. 72 No. 3 September 1983, pp. 440
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BCG Vaccine and Isoniazid Prophylaxis

PHILIP A. BRUNELL MD1

1 Chairman, Committee on Infectious Diseases

In Reply.—

The Committee on Infectious Diseases, after carefully considering the advice of its consultants and reviewing the available data, recommends that isoniazid (INH) should not be used concurrently with bacillus Calmette-Guerin (BCG). As indicated in the most recent report of the Committee,1 there is concern about the protection conferred by BCG,2,3 even when it is given without INH. To administer a drug that inhibits the replication of BCG, therefore, appears to be imprudent.

That INH inhiits the replication of BCG is generally acknowledged.