PEDIATRICS Vol. 72 No. 3 September 1983, pp. 399-404
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Postnatal Development of Circadian Rhythm in Serum Cortisol Levels in Children

Shoju Onishi MD1, Genji Miyazawa MD1, Yutaka Nishimura MD1, Satoru Sugiyama MD1, Takeshi Yamakawa MD1, Hiroshi Inagaki MD1, Toshiyuki Katoh MD1, Susumu Itoh MD1, and Kenichi lsobe MD1

1 From the Department of Pediatrics, Kagawa Medical School, Miki, Kitagun, Kagawa; Department of Pediatrics, Nagoya City University Medical School, Kawasumi, Mizuhoku, Nagoya; and Toyohashi Shimin Hospital, Toyohashi, Japan

High-pressure liquid chromatography was used to study the development of blood adrenocortical circadian rhythm in a total of 64 children, ranging in age from 1 month to 15 years. Patients with endocrine diseases, congenital anomalies, and diseases of the central nervous system were excluded from this study. Determination of corticosteroid concentration was possible with 20 to 100 µL of serum. Twenty-four hour patterns were determined at six-hour intervals. A distinct circadian rhythm with an amplitude comparable to that of an adult emerged at approximately 6 months of age.

Key Words: serum cortisol levels • circadian rhythm • postnatal development • high-pressure liquid chromatography • Halberg's cosinor analysis

Submitted on August 25, 1982
Accepted on November 30, 1982




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