PEDIATRICS Vol. 72 No. 3 September 1983, pp. 291-294
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Five-Year Follow-up Study of Recipients of Live Varicella Vaccine Using Enhanced Neutralization and Fluorescent Antibody Membrane Antigen Assays

Yoshizo Asano MD1, Paul Albrecht MD1, Luba K. Vujcic 1, Gerald V. Quinnan Jr MD1, Katsuro Kawakami MD1, and Michiaki Takahashi MD1

1 From the Division of Virology, Office of Biologics, National Center for Drugs and Biologics, Food and Drug Administration, Bethesda, Maryland; Department of Pediatrics, Osaka Medical College, and Department of Virology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

Twenty-six healthy children susceptible to varicella were inoculated with the OKA strain of live attenuated varicella vaccine. All of the recipients showed good antibody responses without adverse clinical reactions. The seropositivity rate 5 years after vaccination was 100% by the enhanced neutralization test and 96% by the fluorescent antibody membrane antigen (FAMA) test. None of the recipients contracted varicella in spite of documented contact exposure. None of the children developed herpes zoster during the 5-year observation period. The results suggest that attenuated varicella vaccine has long-term protective efficacy.

Key Words: varicella • live vaccine • immunity

Submitted on August 30, 1982
Accepted on December 22, 1982




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[Abstract] [Full Text]