PEDIATRICS Vol. 72 No. 2 August 1983, pp. 263-264
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Screening for Hypothyroidism

Howard W. Kilbride MC1, Robert J. Lull MC2, and Heinz G. Lehman 2

1 Department of Pediatrics, Letterman Army Medical Center, Presidio of San Francisco, CA 94129
2 Nuclear Medicine Service, Department of Radiology, Letterman Army Medical Center, Presidio of San Francisco, CA 94129

Although the New England Regional Screening Program report1 indicates that human error is the most likely cause of failure to detect congenital hypothyroidism in infants, our experience suggests that compensated hypothyroidism might be missed in some newborns unless screening includes a thyroid-stimulating hormone (TSH) assay and a thyroxine (T4) concentration. In the past 2 years, we have diagnosed congenital hypothyroidism in three infants. In at least one of these infants, the disease would not have been identified by T4 concentration screening alone.