PEDIATRICS Vol. 72 No. 2 August 1983, pp. 159-163
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Retinopathy of Prematurity: Incidence and Risk Factors

Mordechai Shohat MD1, Salomon H. Reisner MB, ChB1, R. Krikler MB, ChB1, Ilana Nissenkorn MD1, Yuval Yassur MD1, and Isac Ben-Sira MD1

1 Neonatal Department and Department of Ophthalmology, Beilinson Medical Center, Petah Tiqva, and Tel Aviv University, Sackler School of Medicine, Tel Aviv Israel

A high incidence of retinopathy of prematurity (ROP) was found in the very low-birth-weight infants discharged from the neonatal intensive care unit during the years 1977 to 1980, in spite of frequent monitoring of oxygen use. Although the yearly incidence of ROP in infants weighing <1,500 g varied between 35% to 36%, none were blind. The medical records of 65 infants with a birth weight between 501 and 1,250 g, surviving in 1979 to 1980, were reviewed in order to find risk factors for ROP. There were no significant differences between the 34 infants with ROP and the 31 infants who did not have ROP in mean birth weight or mean gestational age. Of 32 possible risk factors examined, the factors significantly associated with ROP were: apnea with mask and bag ventilation; prolonged parenteral nutrition; number of blood transfusions; and episodes of hypoxemia, hypercarbia, and hypocarbia. A highly significant association between hypocarbia and the development of severe ROP was found.

Submitted on April 19, 1982
Accepted on December 22, 1982




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