PEDIATRICS Vol. 72 No. 1 July 1983, pp. 56-59
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Methylphenidate Hydrochloride Given With or Before Breakfast: II. Effects on Plasma Concentration of Methylphenidate and Ritalinic Acid

Ying-Pui Mick Chan PhD1, James M. Swanson PhD1, Steven S. Soldin PhD1, J. J. Thiessen PhD1, Stuart M. Macleod MD, PhD1, and William Logan MD, PhD1

1 From the Research Institute, The Hospital for Sick Children, and University of Toronto, Toronto, Department of Psychiatry and Human Behavior, University of California Irvine Medical Center, Irvine, and Fairview State Hospital, Costa Mesa, California

Methylphenidate HCl (Ritalin) is often prescribed for the treatment of hyperactivity and is usually administered orally 30 minutes to 1 hour before meals, based on an assumption that meals may interfere with the absorption or metabolism of the drug. Seven boys who were taking methylphenidate regularly for the treatment of hyperactivity were hospitalized and given their established dose of the drug intravenously or orally, either with breakfast or in a fasted state. Blood samples were taken to determine the pharmacokinetics of the drug in each condition. Few differences between the "fed" and "fasted" states were noted, but the statistically significant differences indicated that meals accelerate rather than impede the absorption of methylphenidate.

Key Words: serum levels • methylphenidate • hyperactivity

Submitted on May 10, 1982
Accepted on October 15, 1982




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