PEDIATRICS Vol. 71 No. 6 June 1983, pp. 985-986
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Temperature, Mitochondria, and Reye's Syndrome

R. DON BROWN PHD1 and JOHN T. WILSON MD2

1 Departments of Pharmacology and Therapeutics, Louisiana State University Medical School, PO Box 33932, Shreveport, LA 71130
2 Departments of Pharmacology and Pediatrics, Louisiana State University Medical School, PO Box 33932, Shreveport, LA 71130

In Reply.—

El-Mallakh raises hypothetical questions about an enhancing effect of fever on mitochondrial damage associated with Reye's syndrome. Our article on aspirin and Reye's syndrome1 emphasized the role of prodromal illness in use of aspirin. Fever was only one of several

[See table in the PDF]

prodormal illness events that were different in patients as compared with control subjects.

Results of our analysis of the epidemiologic data from the Ohio study reveal a statistically significant higher temperature in those children which Reye's syndrome as compared with unmatched control subjects (Table) as well as in patients and control subjects matched for record temperatures.1