PEDIATRICS Vol. 71 No. 6 June 1983, pp. 932-933
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Elevation of cAMP Levels in Cerebrospinal Fluid of Patients with Neonatal Meningitis

Ching-Yuang Lin MD1 and Makoto Ishida MD1

1 From the Department of Pediatrics, Mackay Memorial Hospital and China Medical College, Taiwan, Republic of China, and Department of Pediatrics, Osaka University Hospital, Osaka University School of Medicine, Osaka, Japan

The cyclic 3',5'-adenosine monophosphate (cAMP) concentrations in the cerebrospinal fluid of 20 children with neonatal bacterial meningitis and aseptic meningitis were measured by radioimmunoassay method. The cAMP levels were found to be significantly elevated above control levels (P < .01) during the acute phase in most of the patients. In the convalescent stage the cAMP concentration was decreased but levels remained significantly elevated (P < .01) in patients with complications. During the acute phase, the cAMP levels were higher in neonatal bacterial meningitis than in aseptic meningitis (P < .01). The results suggest that cAMP is a sensitive indicator of transient cellular metabolic disturbance in the brain and may be used to monitor the course of neonatal meningitis.

Key Words: cyclic 3',5'-adenosine monophosphate • neonatal bacterial meningitis • aseptic meningitis

Submitted on June 9, 1982
Accepted on August 10, 1982




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H. R. Stutman and M. I. Marks
Bacterial Meningitis in Children: Diagnosis and Therapy: A Review of Recent Developments
Clinical Pediatrics, September 1, 1987; 26(9): 431 - 438.
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