PEDIATRICS Vol. 71 No. 6 June 1983, pp. 913-917
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Hyaline Membrane Disease Treated with Bovine Surfactant

J. A. Smyth MD1, I. L. Metcalfe MSc1, P. Duffty MRCP1, F. Possmayer PhD1, M. H. Bryan MD1, and G. Enhorning MD1

1 From the Department of Paediatrics, University of Toronto and The Hospital for Sick Children, Toronto; Department of Obstetrics and Gynaecology, University of Toronto, and Toronto Western Hospital, Toronto; and Department of Obstetrics and Gynaecology, University of Western Ontario, London, Ontario, Canada

Six preterm infants with severe hyaline membrane disease requiring ventilation were treated, at a median age of 15.5 hours, with a single intratracheal bolus of a bovine surfactant suspension. Arterial oxygenation increased dramatically, and chest radiograms showed improvement after two to four hours. However, a variable degree of deterioration occurred within 24 hours. All of the infants required oxygen therapy for several weeks, and one developed severe bronchopulmonary dysplasia.

Key Words: surfactant adsorption • phospholipids • bubble surfactometer • intracranial hemorrhage • arterial to alveolar oxygen tension ratio

Submitted on January 12, 1983
Accepted on March 10, 1983




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