PEDIATRICS Vol. 71 No. 5 May 1983, pp. 861
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Decreased Prostacyclin Levels in Sickle Cell Disease

PAULETTE MEHTA MD1 and LORETO ALBIOL MD1

1 Department of Pediatrics, University of Florida, College of Medicine, Gainesville, FL 32610

In Reply.—

We read with interest the letter by Longenecker and Mankad regarding measurements of prostacyclin metabolites in patients with sickle cell disease. The major difficulty in this area has been variability of measurements inasmuch as radioimmunoassay measurements of 6-keto-PGF1agr of less than 100 pg/mL are considered unreliable.

The data given by Longenecker and Mankad raise some important questions. The normal levels of 6-keto-PGF1agr, which they found, are similar to those detected by us. In contrast to our findings, patients with sickle cell disease had even lower concentrations which are in undetectable range for this assay and are therefore not reliable.