PEDIATRICS Vol. 71 No. 5 May 1983, pp. 860-861
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Decreased Prostacyclin Levels in Sickle Cell Disease

GESINA L. LONGENECKER PHD1 and VIPUL MANKAD MD2

1 Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL 36688
2 Department of Pediatrics, College of Medicine, University of South Alabama, Mobile, AL 36688

To the Editor.—

Mehta and Albiol1 recently reported grossly elevated plasma levels of the antiplatelet prostanoid, prostacyclin, in sickle cell disease (SCD), and proposed this as the (a) mechanism whereby platelet function in this disorder suppressed. The latter has been reported by others2 and was confirmed by Mehta and Albiol, but is not a universal finding.3 Our data concerning prostacyclin levels in SCD differ dramatically.4 Using serum derived from whole blood treated with indomethacin (a modification of the method of Patrono et al5 for thromboxane B2), with radioimmunoassay (RIA) (New England Nuclear) for the prostacyclin metabolite, 6-keto-PGF1agr, levels (picograms per milliliter) occurred in the order:




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