PEDIATRICS Vol. 71 No. 5 May 1983, pp. 841-842
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Excretion of Technetium in Human Milk

M. JEFFREY MAISELS MB, BCH1 and RONALD O. GILCHER MD2

1 Department of Pediatrics, The Milton S. Hershey Medical Center, Hershey, Pennsylvania
2 Department of Hematology, Walter Reed Army Institute of Research, Washington, DC

The radioisotope technetium-99m(99mTc) is widely used in nuclear medicine for a variety of scanning procedures. On occasion, it may be necessary to perform such studies on a nursing mother, and it is important to know what dose of radioactive material a nursing infant might receive and how soon after the isotope administration the mother may resume breast-feeding.

Technetium is one of the halide elements and is handled, biologically, much like iodine.1 Like iodide,2,3 the pertechnetate ion (99mTcO4-) is concentrated in the thyroid gland1,4 and stomach5,6 and in the breast milk of nursing mothers4-6 and women with the amenorrhea-galactorrhea syndrome.7 In this report we present studies on 99mTcO4- in breast milk, including its binding to milk protein, biologic half-life, and calculations of radioactivity that might be ingested by a nursing infant.




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