PEDIATRICS Vol. 71 No. 5 May 1983, pp. 839-840
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Reversible Reduction in Renal Function During Treatment with Captopril

RICHARD D. COLAVITA MD1, KAREN M. GAUDIO MD1, and NORMAN J. SIEGEL MD1

1 Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut

Captopril is known to be effective for the control of hypertension in adults.1,2 Several recent reports have described the efficacy of this drug in children3,4 and neonates.5 Side effects include neutropenia, proteinuria, rashes, ageusia, hypotension, and hyperkalemia. Farrow and Wilkinson6 described a case of reversible renal failure during therapy with captopril in a young woman with severe hypertension secondary to renal artery stenosis. However, renal failure is not a well-appreciated side effect of this drug and has not been described previously in a pediatric patient during treatment with captopril. We report two cases in which a reversible decline in renal function occurred in children being treated with captopril.