PEDIATRICS Vol. 71 No. 4 April 1983, pp. 671-672
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Probable Graft-Versus-Graft Reaction

JOHN H. GITHENS MD1, ANTHONY R. HAYWARD MD1, and BRIAN A. LAUER MD1

1 Department of Pediatrics, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262

In Reply.—

Buckner points out the difficulty in distinguishing a generalized viral infection from a graft-versus-host reaction (GVHR) on a clinical basis in the immunologically deficient infant. This was the initial differential diagnosis raised in our recent case report1 of an infant believed to have GVHR following an exchange transfusion. Although the presence of donor lymphocytes could not be documented in the blood by HLA typing in our case, we believe the evidence strongly favors the diagnosis of a GVHR rather than a generalized viral infection.