PEDIATRICS Vol. 71 No. 4 April 1983, pp. 615-619
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sahney, S.
Right arrow Articles by Sessums, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sahney, S.
Right arrow Articles by Sessums, L.

Hemoperfusion in Theophylline Neurotoxicity

Shobha Sahney MD1, Jorge Abarzua MD1, and Linda Sessums MD1

1 From the Department of Pediatrics, Division of Nephrology, and Department of Medicine, Divisions of Allergy and Clinical Immunology and Nephrology, Henry Ford Hospital, Detroit

Four patients with severe theophylline toxicity (theophylline levels of 60 to 180 µg/ml) are reported. Three patients with neurotoxicity were treated with hemoperfusion. Two of these were hemoperfused early after the onset of seizures; they recovered with no neurologic deficit. In the third patient hemoperfusion was delayed for 16 hours after uncontrolled seizures; severe brain damage resulted. The fourth patient, who had the highest peak theophylline level but no seizures, was successfully treated with conservative management and peritoneal dialysis. The role of hemoperfusion in severe theophylline intoxication is discussed.

Key Words: theophylline toxicity • hemoperfusion • seizures

Submitted on December 29, 1981
Accepted on February 18, 1982