PEDIATRICS Vol. 71 No. 4 April 1983, pp. 599-602
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Infants Weighing 1,000 Grams or Less at Birth: Developmental Outcome for Ventilated and Nonventilated Infants

Alan D. Rothberg MB, BCh, FCP(SA)1, M. Jeffrey Maisels MB, BCh1, Stephen Bagnato PhD1, James Murphy PhD1, Kathleen Gifford RNC1, and Karen Mckinley RN1

1 From the Division of Newborn Medicine, Department of Pediatrics, The Milton S. Hershey Medical Center, and The Program in School Psychology, The Pennsylvania State University, Hershey

The neurodevelopmental outcome at a mean age of 40 months was investigated in 23/25 surviving infants of birth weights le1,000 gm. Eight infants required intubation and assisted ventilation and 17 were not ventilated. One ventilated infant was lost to follow-up and one nonventilated infant was a victim of sudden infant death syndrome at age 6 months. Fifteen (65%) had a good outcome but the differences between ventilated and nonventilated infants were striking. Thirteen (81%) of the nonventilated group were normal, but only two ventilated survivors (28%) were normal (P < 0.05). Cicatricial retrolental fibroplasia occurred in three (43%) of the ventilated survivors and in none of the nonventilated infants (P < .02). The requirement for assisted ventilation in these very low-birth-weight infants is associated with significant morbidity. Improvement in outcome may depend as much upon better understanding and management of prenatal events as upon improvements in neonatal care.

Key Words: very low-birth-weight infants • developmental outcome • assited ventilation

Submitted on December 14, 1981




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