PEDIATRICS Vol. 71 No. 4 April 1983, pp. 588-593
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The Clinical Significance of Placental Villous Edema

Richard L. Naeye MD1, M. Jeffrey Maisels MB, BCh1, Robert P. Lorenz MD1, and John J. Botti MD1

1 From the Departments of Pathology, Pediatrics, and Obstetrics and Gynecology, M. S. Hershey Medical Center, The Pennsylvania State University College of Medicine, Hershey

A study was undertaken to determine why there is such variability in morbidity and mortality in neonates exposed to antenatal chorioamnionitis. Villous edema provides a clue. It was present in 72/83 placentas with chorioamnionitis. The extent and severity of the edema had a strong, positive correlation with cord arterial blood pH values, low Apgar scores, the need to resuscitate vigorously at birth, the subsequent need for assisted ventilation, the frequency of hyaline membrane disease, and neonatal mortality. Most of the difference in morbidity and mortality between preterm and full-term infants was related to the greater severity and extent of villous edema in those born prematurely.

Key Words: Apgar score • chorioamnionitis • neonate • placenta • respiratory distress

Submitted on December 7, 1981
Accepted on March 16, 1982




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