PEDIATRICS Vol. 71 No. 4 April 1983, pp. 576-580
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Short Stature Associated with Normal Growth Hormone and Decreased Somatomedin-C Concentrations: Response to Exogenous Growth Hormone

C. M. Bright MD1, A. D. Rogol MD, PhD1, A. J. Johanson MD1, and R. M. Blizzard MD1

1 From the Divisions of Endocrinology and Diabetes and Clinical Pharmacology, Departments of Pediatrics and Pharmacology, University of Virginia Medical Center, Charlottesville

Two prepubertal males with low somatomedin-C concentrations in their sera, but normal growth hormone concentrations, had positive metabolic responses when human growth hormone was administered. An accelerated velocity of growth accompanied the longterm administration of growth hormone. This response was dependent upon the administration of exogenous hormone inasmuch as linear growth was subnormal both before and after administration of growth hormone. The extreme short stature in these individuals may be secondary to a biologically inactive growth hormone molecule that is immunologically reactive or to a decreased dose responsiveness of the cells that produce somatomedin when exposed to the usual concentrations of endogenous growth hormone.

Key Words: short stature • growth hormone • somatomedin-C

Accepted on December 24, 1981




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