PEDIATRICS Vol. 71 No. 3 March 1983, pp. 383-388
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Decreased Bone Mineral Content in Small-for-Gestational-Age Infants Compared with Appropriate-for-Gestational-Age Infants: Normal Serum 25-Hydroxyvitamin D and Decreasing Parathyroid Hormone

Stephen D. Minton MD1, Jean J. Steichen MD1, and Reginald C. Tsang MBBS1

1 From the Crosley Memorial Nursery, University of Cincinnati Hospital; Newborn Division, Departments of Pediatrics, Obstetrics and Gynecology, University of Cincinnati College of Medicine, and Children's Hospital Research Foundation, Cincinnati

Bone mineral content was determined by photon absorptiometry, adapted for use in neonates, in 23 small-for-gestational-age (SGA) infants of 31 to 42 weeks of gestational age, for 12 weeks. At birth, term SGA infants had lower bone mineral content than term appropiate-for-gestational-age (AGA) infants; postnatal increase in bone mineral content was slow and lagged significantly behind that of term AGA infants. Preterm SGA infants had bone mineral content that was similar to that of preterm AGA infants at birth; postnatal bone mineral content was similar to that of preterm AGA infants, but was decreased compared with the expected intrauterine bone mineral content. Serum 25-hydroxyvitamin D concentrations and parathyroid hormone levels were the same for SGA and AGA infants. Serum 25-hydroxyvitamin D concentrations decreased slightly with postnatal age and remained within normal limits. Serum parathyroid hormone concentrations decreased in both SGA and AGA infants and reached undetectable levels at 10 to 12 weeks of age.

Key Words: small for gestational age infants • bone mineralization • photon absorptiometry • vitamin D • parathyroid hormone

Submitted on February 1, 1982
Accepted on June 9, 1982




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