PEDIATRICS Vol. 71 No. 2 February 1983, pp. 294-295
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Aspirin Consumption and Severity of Reye's Syndrome

KAREN M. STARKO MD1

1 Maricopa County Department of Health Services, Phoenix, AZ 85008

In Reply.—

The Center for Disease Control,1 the Committee on Infectious Diseases of the American Academy of Pediatrics,2 and The Food and Drug Administration,3 have concluded that the studies conducted in Arizona,4 Michigan,5 and Ohio6 indicate that a statistically significant association exists between Reye's syndrome (RS) and salicylate use. Reasons for this association being false, such as case-control misclassification, the influence of confounding variables (fever, headache) etc, have been addressed by these groups. Although concerns have been raised regarding these factors, none has been shown to account for the association.