PEDIATRICS Vol. 71 No. 2 February 1983, pp. 253-256
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Campylobacter jejuni-Associated Hemolytic-Uremic Syndrome in a Mother and Daughter

Bruce N. Chamovitz MD1, Alan I. Hartstein MD1, Steven R. Alexander MD1, Annie B. Terry MD1, Priscilla Short MD1, and Ronald Katon MD1

1 From the Departments of Internal Medicine and Pediatrics, Oregon Health Sciences University, Portland

A mother and daughter with Campylobacter jejuni-associated hemolytic-uremic syndrome (HUS) are discussed. The mother was hospitalized with bloody diarrhea and HUS; C jejuni was isolated from her stool. The 2-year-old daughter had been admitted five days prior to her mother with HUS following a three-day prodrome of vomiting and diarrhea. Multiple stool cultures were negative for enteric pathogens; however, cultures were not obtained until the eighth hospital day and after antibiotic therapy. Extensive investigation failed to identify another cause for the diarrheal illness or HUS in our patients. Indirect immunofluorescent antibody titers for C jejuni were 1:32 and 1:16 for the mother and daughter, respectively. An asymptomatic 9-month-old son had C jejuni isolated from his stool and had an immunofluorescent antibody titer of 1:64. Three other family members were asymptomatic, stool-culture negative, and had immunofluorescent antibody titers le 1:4. The susceptibility to develop HUS following an enteric antigenic stimulus is illustrated by the patients presented. The need for systematic investigation of all HUS cases for potential susceptibility markers, as well as an exhaustive etiologic search, is emphasized.

Key Words: Campylobacter jejuni • hemolytic-uremic syndrome

Submitted on February 19, 1982
Accepted on May 3, 1982




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V. H. San Joaquin and D. F. Welch
Campylobacter Enteritis: A 3-Year Experience
Clinical Pediatrics, June 1, 1984; 23(6): 311 - 316.
[Abstract] [PDF]