PEDIATRICS Vol. 71 No. 2 February 1983, pp. 196-199
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Cyclacillin Versus Amoxicillin as Treatment for Acute Otitis Media

Samuel E. McLinn MD1 and Steven Serlin MD1

1 From the Scottsdale Pediatric Center, Scottsdale, Arizona

A double-blind study of 240 pediatric outpatients with acute otitis media demonstrated that cyclacillin administered three times a day for ten days, is as effective as and better tolerated than a similar regimen of amoxicillin. Clinical success was achieved in 96% of the children treated with each drug, and the bacteriologic cure rate was 98% in each treatment group. Only three of the 119 children (2.5%) treated with cyclacillin had drug-related diarrhea, in contrast to 17/121 children (14%) treated with amoxicllin (P <.01). This greater tolerance for cyclacillin may be due to its more effective and rapid absorption in the upper gastrointestinal tract. The results are discussed in terms of the low incidence of resistant strains of Haemophilus influenzae and the advantages of cyclacillin as the first-line treatment for acute otitis media.

Key Words: cyclacillin • amoxicillin • acute otitis media • Haemophilus influenzae

Submitted on February 16, 1982
Accepted on May 3, 1982