PEDIATRICS Vol. 71 No. 1 January 1983, pp. 19-22
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Risk Factors for Necrotizing Enterocolitis in Infants Weighing More Than 2,000 Grams at Birth: A Case-Control Study

Rickey Wilson MD1, Madeline del Portillo MD1, Emmet Schmidt MD, PhD1, Roger A. Feldman MD1, and William P. Kanto Jr MD1

1 From the Enteric Diseases Branch, Bacterial Diseases Division, Center for Infectious Diseases, Centers for Disease Control, Atlanta; Department of Pediatrics, Emory University School of Medicine, Atlanta; and Department of Pediatrics, Texas Tech University Health Sciences Center, Amarillo

A retrospective case-control study of necrotizing enterocolitis (NEC) was conducted among infants weighing >2,000 g at birth. Twenty-three infants met the NEC criteria for inclusion in the study; 12 weighed 2,001 to 2,500 g at birth and 11 weighed >2,500 g at birth. Hypoglycemia occurred in 7/12 (55%) infants weighing 2,001 to 2,500 g and in 4/35 (11%) control subjects (P < .02). In infants weighing >2,500 g at birth, polycythemia (occurring in 7/12 study infants (58%) and 5/32 (16%) control infants) and respiratory distress (3/11 study infants (27%) and 0 control subjects) were significantly associated with NEC (P < .02). Larger infants with a history of perinatal stress and/or physiologic immaturity are likely to be at greater risk for NEC than their normal counterparts.

Key Words: necrotizing enterocolitis • term infant • risk factors • polycythemia • hypoglycemia

Submitted on April 2, 1982




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