PEDIATRICS Vol. 71 No. 1 January 1983, pp. 140-141
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by TOBACK, J. W.
Right arrow Articles by GILMAN, M. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by TOBACK, J. W.
Right arrow Articles by GILMAN, M. E.

Theophylline-Furosemide Inactivation?

JAMIE W. TOBACK PHARMD1 and MILES E. GILMAN PHARMD2

1 Crawford W. Long Memorial Hospital of Emory University, Atlanta, GA 30365
2 Baptist Hospital of Miami, Miami, FL 33173

To the Editor.—

A recent report by Nakagawa1 suggested a possible increased theophylline clearance when furosemide was concomitantly administered. He postulated a decreased hepatic congestion with furosemide which increased theophylline clearance. Conlon et al2 originally investigated this possible interaction but reported an increase in serum theophylline levels, probably due to the apparent volume of distribution contraction associated with diuresis. Conversely, we have observed premature neonates whose serum theophylline concentrations have decreased when furosemide was administered simultaneously.