PEDIATRICS Vol. 71 No. 1 January 1983, pp. 137
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Fab Fragments in Treatment of Digoxin Ingestion

THOMAS W. SMITH MD1

1 Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115

To the Editor.—

Accompanying the paper of Zucker et al in the September issue of Pediatrics1 is a listing of sources from which digoxin-specific Fab fragments are stated to be available. Unfortunately, this is no longer the case. All of the individuals and institutions listed have been part of a multicenter trial of clinical safety and efficacy of purified digoxin-specific Fab fragments in the treatment of advanced, life-threatening digitalis toxicity. At the present time, however, supplies of the material are extremely limited, and several of the centers listed have exhausted their supplies of digoxin-specific Fab fragments.