PEDIATRICS Vol. 70 No. 6 December 1982, pp. 895-900
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National Surveillance for Reye Syndrome: A Five-Year Review

Eugene S. Hurwitz MD1, David B. Nelson MD1, Cornelia Davis MD1, David Morens MD1, and Lawrence B. Schonberger MD, MPH1

1 The Viral Diseases Division, Center for Infectious Diseases, Centers for Disease Control, Atlanta

National surveillance for Reye syndrome conducted during five years, including the period 1973-1974 and December 1976 through November 1980, has resulted in the reporting of more than 2,000 cases of Reye syndrome. The highest reported incidence of Reye syndrome occurred during years of primary influenza B and A (H1N1) activity; the reported incidence during one period of influenza A (H3N2) activity was somewhat lower. Regional outbreaks of Reye syndrome have been associated with influenza A (H1N1) and B but not with influenza A (H3N2). Cases of Reye syndrome in whites tend to be distributed throughout all age groups whereas a large percentage of cases in blacks have been reported in infants <1 year of age in three of the past four years. Nationally, there has been a decline in the case-fatality ratio in recent years.

Key Words: Reye syndrome • influenza • varicella

Submitted on November 12, 1981
Accepted on March 5, 1982




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