PEDIATRICS Vol. 70 No. 4 October 1982, pp. 633-637
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The Relation Between Glucose Tolerance and Insulin Binding to Circulating Monocytes in Obese Children

Kaichi Kida MD, PhD1, Noriyoshi Watanabe MD1, Yoshiki Fujisawa MD1, Yoshinori Goto MD1, and Hiroshi Matsuda MD1

1 Department of Pediatrics, Ehime University School of Medicine, Shigenobu, Ehime 791-02, Japan

The quantitative relation between insulin binding to circulating monocytes in vitro and glucose tolerance in obese children in vivo is reported. Sixty-one obese children and 11 healthy control children participated in this study. The oral glucose tolerance test (OGTT) was performed by giving them glucose (1.75 gm/kg of body weight), orally in the morning, and the binding of 125I-labeled insulin to circulating monocytes in vitro was measured prior to OGTT. The glucose tolerance expressed by SgrBS (milligrams/100 ml), the sum of the plasma glucose (blood sugar [BS]) values at OGTT, was significantly correlated with the degree of overweight (r = .316, P < .01) and more highly with SgrIRI (microunits per milliliter), the sum of immunoreactive insulin (IRI) values at OGTT (r = .512, P < .001). Insulin binding to monocytes in vitro (picograms/106 cells) was inversely correlated with the degree of overweight (r = -. 687, P < .001). Furthermore, SgrBS was inversely correlated significantly with insulin binding to monocytes in vitro (r = -.435, P < .002). These data suggest that the decrease of insulin receptors might be one cause for the impairment of the glucose tolerance associated with obesity in children.

Submitted on November 2, 1981
Accepted on February 2, 1982