PEDIATRICS Vol. 70 No. 4 October 1982, pp. 560-565
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Pediatric Nocardiosis

Barbara J. Law MD1 and Melvin I. Marks MD1

1 Division of Pediatric Infectious Diseases, University of Oklahoma Health Sciences Center, Oklahoma City

Characteristics of Nocardia infection, which occurred in ten Oklahoma children between 1975 and 1980, are described. Fatal N asteroides infection occurred in three immunocompromised patients. Pneumonia was the presenting feature in each; one patient had disseminated disease. The first reported case of shunt-associated N asteroides ventriculitis occurred in a 2-month-old girl, who was successfully treated with oral trimethoprim-sul-famethoxazole. N brasiliensis was isolated from six immunologically competent children, five of whom had localized, uncomplicated, cutaneous infections. The sixth child developed osteomyelitis following a compound skull fracture. Based on this experience and a review of the literature, N asteroides infections are associated with immunocompromised hosts, and usually are seen as pneumonia with occasional dissemination to other sites. In contrast, N brasiliensis infections are more common than previously thought and usually occur in otherwise normal children as acute posttraumatic pyoderma.

Submitted on September 14, 1981
Accepted on October 21, 1981




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A. K. Shetty, A. M. Arvin, and K. M. Gutierrez
Nocardia farcinica Pneumonia in Chronic Granulomatous Disease
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