PEDIATRICS Vol. 70 No. 4 October 1982, pp. 557-559
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Perinatal Transmitted Acute Icteric Hepatitis B in Infants Born to Hepatitis B Surface Antigen-Positive and Anti-hepatitis Be-Positive Carrier Mothers

Frank R. Sinatra MD1, Praful Shah MD1, Joy Y. Weissman MD1, Daniel W. Thomas MD1, Russell J. Merritt MD, PhD1, and Myron J. Tong PhD, MD1

1 Gastroenterology Program, Children's Hospital of Los Angeles, and Liver Center, Huntington Memorial Hospital, Pasadena, California

Three infants born to mothers who were hepatitis B surface antigen (HBsAg) positive and had antibody to hepatitis Be antigen (anti-HBe), developed acute icteric hepatitis B within three months of birth. All three infants clinically recovered and developed circulating anti-HBs. Contrary to previous studies, these three cases indicate that mother-infant transmission of the hepatitis B virus (HBV) does occur in infants born to HBsAg-positive, HBeAg-negative carrier mothers, and these infants may develop severe acute icteric hepatitis. Therefore, immunoprophylaxis in such newborns may be indicated.

Submitted on January 18, 1982
Accepted on March 2, 1982




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