PEDIATRICS Vol. 70 No. 3 September 1982, pp. 447-450
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lees, M. H.
Right arrow Articles by Sunderland, C. O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lees, M. H.
Right arrow Articles by Sunderland, C. O.

Chloral Hydrate and the Carbon Dioxide Chemoreceptor Response: A Study of Puppies and Infants

Martin H. Lees MD1, George D. Olsen MD1, Kip L. McGilliard PhD1, James D. Newcomb BA1, and Cecille O. Sunderland MD1

1 Departments of Pediatrics and Pharmacology, Oregon Health Sciences University, Portland

CO2 chemoreceptor function was assessed during natural sleep and following the administration of 100 mg/kg of chloral hydrate to 26 puppies. With chloral hydrate-induced sleep, there were no significant changes in ventilation or in CO2 chemoreceptor response. The ventilation and CO2 chemoreceptor response of a group of infants in natural sleep were compared with those of a group receiving 50 mg/kg of chloral hydrate. Tidal volume, O2 consumption, and CO2 elimination were slightly higher in the group given chloral hydrate. There was no difference in the CO2 chemoreceptor response. The proportion of time spent in rapid eye movement (REM) and non-rapid eye movement (NREM) sleep in chloral hydrate-induced sleep was similar to that occurring in natural sleep. Use of chloral hydrate stabilizes O2 consumption and CO2 production, and it greatly facilitates the assessment of chemoreceptor function in infants. The CO2 chemoreceptor response appears not to be altered in puppies or infants.

Submitted on April 13, 1981
Accepted on September 15, 1981




This article has been cited by other articles:


Home page
 PediatricsHome page
C. J. Coté, H. W. Karl, D. A. Notterman, J. A. Weinberg, and C. McCloskey
Adverse Sedation Events in Pediatrics: Analysis of Medications Used for Sedation
Pediatrics, October 1, 2000; 106(4): 633 - 644.
[Abstract] [Full Text]