PEDIATRICS Vol. 70 No. 1 July 1982, pp. 48-51
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Mast Cells in Hemangiomas and Vascular Malformations

Julie Glowacki PhD1 and John B. Mulliken MD1

1 Division of Plastic Surgery and Department of Surgery, The Children's Hospital Medical Center and Brigham and Women's Hospital, Harvard Medical School, Boston

Common pediatric vascular birthmarks, classified as hemangiomas or malformations, were analyzed for the presence of mast cells. Hemangiomas in the proliferative phase contained large numbers of mast cells (27 ± 15 cells/high-power field [HPF]) in comparison with hemangiomas in the involuting phase (2.6 ± 2.9), vascular malformations (1.7 ± 3.2), and normal skin (5.0 ± 1.0). Inasmuch as hemangiomas are characterized by endothelial proliferation and increased numbers of mast cells, these data raise the possibility that mast cells may have an important role in the formation and/or maintenance of these lesions.

Submitted on June 8, 1981
Accepted on July 29, 1981




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