PEDIATRICS Vol. 7 No. 6 June 1951, pp. 760-773
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GALACTOSEMIA AND ITS RELATION TO LAENNEC'S CIRRHOSIS

Review of the Literature and Presentation of Six Additional Cases

EDWARD H. TOWNSEND JR. M.D.1, HOWARD H. MASON M.D.1, and PAUL S. STRONG M.D.1

1 Babies Hospital and the Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York City.

Five additional cases of galactosemia are added to the steadily increasing number of reports in the literature. A follow-up note is included regarding a sixth case in a patient now 18 years of age, previously reported from this hospital.

Two of these cases developed cirrhosis of the liver in a manner suggesting that galactosemia per se was the cause. Histologic examination of the liver in both cases confirmed the anatomic diagnosis.

A 10 year follow-up on Mason and Turner's reported Case 7 demonstrates that the illness is chronic but that with advancing years, demonstrable evidence of somatic damage is lacking. Mental retardation is a common complication of the disorder in the present investigators' experience. Cirrhosis of the liver accompanying galactosemia appears to be reversible, so far as can be determined.

Submitted on December 14, 1950




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