PEDIATRICS Vol. 7 No. 2 February 1951, pp. 186-192
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TISSUE CHANGES IN THE NEPHROTIC SYNDROME: DEMONSTRATION OF POTASSIUM DEPLETION

CHARLES L. FOX JR. M.D.1 and LAWRENCE B. SLOBODY M.D.2

1 The Department of Bacteriology, College of Physicians and Surgeons, Columbia University
2 The Department of Pediatrics, New York Medical College, Flower and Fifth Avenue Hospitals, New York.

Analyses of skeletal muscles, obtained at autopsy from six children with the nephrotic syndrome, reveal losses of from one fourth to two thirds of their potassium content per unit dry weight or cell solids. Their phosphorus content is only moderately reduced. These muscles have gained large amounts of water, sodium and chloride in ratios approximating extracellular fluid.

The muscle values are compared with other types of potassium loss from muscle, e.g., after experimental potassium deprivation, desoxycorticosterone therapy, alkalosis and muscle trauma.

Since potassium is the intracellular cation, its depletion may be associated with important effects on intracellular anions, enzymes or catalysts and, together with cellular hydration and hypotonicity, contribute to the physiologic alterations found in this syndrome.

Analyses of kidneys from these patients reveal somewhat similar changes; liver, in contrast, showed minimal alteration.

Submitted on July 6, 1950


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C. L. Fox Jr., J. M. Winfield, L. B. Slobody, C. M. Swindler, and J. K. Lattimer
ELECTROLYTE SOLUTION APPROXIMATING PLASMA CONCENTRATIONS: WITH INCREASED POTASSIUM FOR ROUTINE FLUID AND ELECTROLYTE REPLACEMENT
JAMA, March 8, 1952; 148(10): 827 - 833.
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