PROGRESS IN THE STUDY OF "MUCOVISCIDOSIS" (PANCREATIC FIBROSIS)

With Illustrative Case Presentations

¹ The Department of Pediatrics, Harvard Medical School, and the Division of Clinical Pathology, The Children's Medical Center and The Children's Cancer Research Foundation, Boston.

IN ACCEPTING the first Mead Johnson Award for the year 1949, I should like to thank those who give it and those who have participated with me in the investigation of nutritional disorders, and particularly of the disease pancreatic fibrosis. I should like to acknowledge the assistance received from Dr. Paul R. Patterson who has been associated with me in most of our studies during the past three years.

Dr. May left the Children's Hospital in Boston over three years ago; it is a pleasure to be reunited with him here and to share this honor. Dr. May and I agreed that it would be difficult for us to attempt a presentation which would cover our independent activities. Instead, I should like to thank him for giving me this opportunity to tell you about some of our recent observations at the Children's Hospital. The advantages of working in an institution, in which a vast amount of energy has been expended over a long period of time in the study of pancreatic fibrosis, is quite obvious. The person most responsible for this activity and progress is Dr. Sidney Farber who has clearly presented a theory concerning the nature of the disease which after many years is being generally accepted. In 1941, he was able to refer to an experience of over 150 patients exhibiting the celiac syndrome studied at post mortem over an 18 year period.

Until recently and with rare exceptions all patients with proved pancreatic fibrosis have died. Nevertheless, I should like to suggest that we have much to gain if we discard the prevailing pessimistic attitude toward this disease (pancreatic fibrosis).

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