PEDIATRICS Vol. 7 No. 1 January 1951, pp. 7-18
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Treatment Of Disseminated Histoplasmosis With Ethyl Vanillate

AMOS CHRISTIE M.D.1, JAMES G. MIDDLETON M.D.1, J. CYRIL PETERSON M.D.1, and DAVID L. MCVICKAR M.D.1

1 The Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, and the Medical Section of the National Tuberculosis Association, Philadelphia.

Some of the physical and pharmacologic properties of ethyl vanillate, a new fungistatic or fungicidal agent, have been briefly stated.

The records of 12 patients with progressive disseminated histoplasmosis treated with ethyl vanillate have been reviewed. Five of these patients are alive and apparently well following treatment, an experience not previously encountered or reported in the literature.

The use of the drug in the treatment of histoplasmosis has been outlined and the toxic manifestations of overdosage have been described.

Submitted on May 15, 1950




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